Animal research is a challenging issue for the animal advocate because of what, besides animal well—being, is considered to be at stake, namely, human health. This article seeks to vindicate the antivivisectionist position. The standard defense of animal research as promoting the overwhelming good of human health is refuted on both factual and logical, or normative—theoretical, grounds. The author then attempts to clinch the case by arguing that animal research violates a deontic principle. However, this principle falls to counterexample. The author concludes, nevertheless, that the principle retains force as a presumption that the current state of affairs fails to overthrow. This does suggest, though, that the antivivisection movement would be well advised to keep ahead of the curve. The author proposes it do so by emulating the vegan movement against animal agriculture with the active promotion of alternatives to animal research.